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Effect of analysis time on optimum column length in time normalization chromatography

✍ Scribed by Eli Grushka; Francis B. Lo

Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
900 KB
Volume
91
Category
Article
ISSN
1873-3778

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✦ Synopsis

The effect of the carrier velocity on the optimum length in time normalization chromatography (or analysis at constant retention time) was investigated.

It was found both theoretically and experimentally that at any given carrier velocity (or analysis time) the resolution can be optimized. The length at which the optimization occurs is a function of the plate height dependence on the temperature. In general, an absolute maximum resolution occurs when operating at carrier velocities around the Van Deemter plot minimum.

It appears that a prediction of the column length can still be made using the approach suggested by us previously. Theoretically, in the case of a capillary column, one can operate at twice the minimum velocity without a large loss in the resolution but at a saving in the analysis time.

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