Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo
β Scribed by Angela M.H. Brodie; Harry J. Brodie; Wesley M. Garrett; James R. Hendrickson; David A. Marsh; Tsai-Morris Chon-Hwa
- Book ID
- 115776374
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 774 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0006-2952
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## Abstract The influence of age at time of DMBA administration on (l) the histopathogenesis and site of mammary tumor origin and (2) the precancerous nature of DMBAβinduced mammary dysplasias was examined in Lewis rats between 25 and 200 days of age. Rats were killed at various times after carcino
The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10