𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of amiodarone on3H-ouabain binding sites in human skeletal muscle

✍ Scribed by A. Nørgaard; J. H. Jensen; F. Andreasen

Publisher
Springer
Year
1990
Tongue
English
Weight
237 KB
Volume
38
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.

✦ Synopsis

Na,K-ATPase, or the Na,K-pump, is essential for the excitability and contractility of muscle tissue. Hypothyroidism in associated with a marked decrease in the Na,K-pump concentration in skeletal muscle and myocardium. In 7 patients on long-term amiodarone treatment there was a 36% reduction in the concentration of 3H-ouabain binding sites in skeletal muscle biopsies compared to 7 healthy subjects. This decrease during long-term amiodarone treatment may represent an equivalent reduction in the concentration of the functional Na,K-pump and it may be important in the adverse effect of amiodarone on muscle.

📜 SIMILAR VOLUMES

Methodological Aspects of Measuring Huma
Methodological Aspects of Measuring Human Skeletal Muscle Electrolyte Content and Ouabain Binding Capacity
✍ M.Stig Djurhuus; Niels A.H. Klitgaard; Claus Tveskov; Klavs Madsen; Bernadette G 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 65 KB

The aim of the study was to evaluate the use of freeze-dried and dissected small muscle biopsy specimens ("dry") for the determination of human muscle electrolyte content and ouabain binding capacity, compared with an easier method, without this freezedrying step ("wet"). Freeze-drying and dissectio