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Effect of aminoguanidine on ischemia-reperfusion induced myocardial injury in rats

✍ Scribed by Hakan Parlakpinar; Mehmet Kaya Ozer; Ahmet Acet

Publisher: Springer
Year: 2005
Tongue: English
Weight: 118 KB
Volume: 277
Category: Article
ISSN: 0300-8177
DOI: 10.1007/s11010-005-5779-9

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Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). In addition to being an inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that aminoguanidine reduces ischaemia-reperfusion (I/R)-induced d