Effect of Amino Acids and Polypeptides on Electrokinetic Properties of Pure Lipid Vesicles and Mixed Vesicles with Crown Ethers
✍ Scribed by Hideo Matsumura; Chiharu Obata; Kiyoko Kawahara; Kunio Furusawa
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 255 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0021-9797
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✦ Synopsis
Electrophoretic mobilities of phospholipid vesicles and mixed vesicles of phospholipid with a crown ether compound have been studied in the presence of amino acids (glutamic acid, lysine, and alanine) or polypeptides. L-lysine has a minor effect on the electrophoretic mobilities, in contrast to l-glutamic acid, which has a peculiar effect on the electrophoretic mobilities. Poly-Lglutamic acid and poly-L-lysine have a strong affinity for phosphatidylcholine vesicles and also for the mixed vesicles, which results in a significant charge effect on the electrophoretic mobilities. The presence of the crown ether ring on the vesicle surface causes not only selective binding effect for the (-\mathrm{NH}_{3}^{+})group of amino acid residues but also a hydration effect which brings the vesicle surface to a more hydrophilic nature. 1993 Academic Press, Inc.