Effect of alpha-interferon on hepatitis C virus chronic infection in mixed cryoglobulinemia patients
โ Scribed by C. Ferri; G. Longombardo; L. La Civita; F. Lombardini; G. Pasero; S. Bombardieri; F. Greco; A. Mazzoni; Anna L. Zignego; Monica Monti; P. Gentilini; M. Manns
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 870 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0300-8126
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Of 74 patients who were infected with hepatitis C virus (HCV) and received interferon, 12 (16%) were positive for RNA of GB virus C (GBV-C). RNA of GBV-C was determined in sera from the co-infected patients retrospectively, and the effect of interferon on GBV-C was compared with that on HCV in them.
Hepatitis C virus RNA as detected by reverse transcription and nested polymerase chain reaction was monitored in 16 patients with chronic hepatitis C treated with interferon. Hepatitis C virus R N A became undetectable after 4 to 8 wk of interferon administration in 13 of the 16 patients. During 6 m
Essential cryoglobulinemia is associated closely with hepatitis C virus (HCV) infection. The mechanism responsible for occurrence of the disease is unclear. The aim of this study was to investigate pathogenetic roles of HCV in cryoglobulinemia. One hundred sixty-seven consecutive patients with HCV w