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Effect of aliphatic aldehydes on the lipid peroxidation and chemiluminescence of biological systems under oxidative stress

✍ Scribed by Videla, L. A. ;Ferrer, V. ;Lissi, E. A.

Publisher: John Wiley and Sons
Year: 1997
Weight: 160 KB
Volume: 12
Category: Article
ISSN: 0884-3996
DOI: 10.1002/(sici)1099-1271(199705/06)12:3<141::aid-bio443>3.0.co;2-2

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✦ Synopsis

The effect of several aliphatic aldehydes on lipid peroxidation was evaluated by measuring the oxygen uptake rate, thiobarbituric acid-reactive products formation and the emitted visible chemiluminescence intensity. Measurements were carried out in brain homogenates and erythrocyte plasma membrane and liver microsomal fractions. In all systems studied, aldehydes (25 mmol/L) (e.g. acetaldehyde, 2,2-dimethylpropanal), increased the intensity of the luminescence associated with the oxidation process. In contrast, aldehyde incorporation decreased TBARS production and the rate of oxygen uptake. The increased luminescence intensity is explained in terms of secondary reactions of aldehyde derived free radicals. These results clearly indicate that extreme care must be exercized in the intepretation of chemiluminescence data in the presence of aldehydes.

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