𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

✍ Scribed by Daniele Bravi; Jeffrey J. Anderson; Fiorenzo Dagani; Thomas L. Davis; Rosaria Ferrari; Marge Gillespie; Dr. Thomas N. Chase

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
380 KB
Volume
7
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Oxygen consumption and enzyme activity were evaluted in platelet mitochondria from 17 patients with Parkinson's disease. In comparison with age‐matched controls, no consistent abnormality could be discerned in complex I, complex II‐III, or complex IV oxygen consumption, or in the enzyme activity of these respiratory chain complexes. Neither chronic therapy with levodopa/carbidopa alone nor in combination with deprenyl significantly affected any measure of mitochondrial respiratory function. There was no discernible relationship between patient age or disease severity and any parameter of mitochondrial respiration. Moreover, blood lactate levels following glucose loading were not different in patients and controls. These results fail to support the occurrence of a generalized defect in any mitochondrial respiratory function in Parkinson's disease.

📜 SIMILAR VOLUMES

Effect of age on geriatric depression sc
Effect of age on geriatric depression scale performance in Parkinson's disease
✍ Daniel Weintraub; Kirsten Saboe; Matthew B. Stern 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 1 views

## Abstract The purpose of this study was to compare the validity of the 15‐item Geriatric Depression Scale (GDS‐15) in nonelderly (<65 years), young‐elderly (age, 65–75), and old‐elderly (>75 years) patients with Parkinson's disease (PD). 57 nonelderly, 88 young‐elderly, and 81 old‐elderly PD pati

Patient-perceived involvement and satisf
Patient-perceived involvement and satisfaction in Parkinson's disease: Effect on therapy decisions and quality of life
✍ Katherine A. Grosset; Donald G. Grosset 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB 👁 1 views

## Abstract Patient‐centered consultation styles are associated with higher patient satisfaction and improved health outcomes in diabetes and hypertension. In outpatient neurology, dissatisfaction with communication relates significantly to noncompliance. We undertook a single‐center study in Parki

Effects of levodopa and subthalamic nucl
Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
✍ Aurélie Funkiewiez; Claire Ardouin; Roshan Cools; Paul Krack; Valérie Fraix; Ali 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 1 views

## Abstract In Parkinson's disease (PD), levodopa and subthalamic nucleus (STN) stimulation lead to major improvement in motor symptoms. Effects of both treatments on cognition and affective status are less well understood. Motor, cognitive, and affective symptoms may relate to the dysfunctioning o