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Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats

✍ Scribed by Yoshikazu Higami; Isao Shimokawa; Tomoaki Okimoto; Masato Tomita; Takane Yuo; Takayoshi Ikeda

Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
838 KB
Volume
288
Category
Article
ISSN
0302-766X

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## Abstract Aging enhances apoptosis of hepatocytes under normal physiological conditions and increases the susceptibility to apoptosis of hepatocytes, whereas chronic calorie restriction (CR) suppresses the age‐enhanced susceptibility to apoptosis. To clarify the subcellular mechanisms of age‐asso