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Effect of age and dietary restriction on protein synthesis by isolated kidney cells

✍ Scribed by Wilbert G. Ricketts; Maria C. Birchenall-Sparks; James P. Hardwick; Arlan Richardson

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
872 KB
Volume
125
Category
Article
ISSN
0021-9541

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✦ Synopsis

The influence of age and food restriction on kidney protein synthesis was studied in Fischer F344 rats. The rate of total protein synthesis by suspensions of kidney cells declined 60% between 4 and 31 months of age. The rate of protein synthesis by kidney cells isolated from 19-month old rats fed a restricted diet (60% of diet consumed by rats fed ad libitum) was 45% higher than t h e rate of protein synthesis by kidney cells isolated from 19-month old rats fed ad libitum. The excretion of protein in the urine was measured to assess t h e effect of t h e age related decline in protein synthesis on kidney function. A dramatic increase in proteinuria was observed with increasing age, and rats fed the restricted diet excreted significantly less protein in the urine than rats fed ad libitum.

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