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Effect of advanced glycation end-products on gene expression and synthesis of TNF-alpha and endothelial nitric oxide synthase by endothelial cells

✍ Scribed by Rashid, Gloria; Benchetrit, Sydney; Fishman, Dina; Bernheim, Jacques


Book ID
109066588
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
161 KB
Volume
66
Category
Article
ISSN
0085-2538

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## Abstract Advanced glycation endproducts (AGEs) accumulate on protein deposits including the β‐amyloid plaques in Alzheimer's disease. AGEs interact with the β€œreceptor for advanced glycation endproducts”, and transmit their signals using intracellular reactive oxygen species as second messengers.