Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide
✍ Scribed by L. F. B. P. Costa Rosa
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 163 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
This study examined the eect of adrenaline on lymphocyte metabolism and function. The following parameters were addressed: cell proliferation, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. We also evaluated the involvement of beta-receptors in this response as well as the possible eect of cAMP and hydrogen peroxide in the process of lymphocyte activation by adrenaline. The results indicated that adrenaline is able to induce metabolic changes in lymphocytes that are related to enhanced proliferative capacity, but under physiological conditions fails to initiate the process, the catecholamine could, increase cell proliferation via increased production of H 2 O 2 by macrophages, since this reactive oxygen intermediate can act as a trigger for lymphocyte activation. The results also showed that distinct populations of lymphocytes present dierent responses to adrenaline activation, as demonstrated by cells obtained from the same site but exposed to dierent mitogens such as LPS and ConA.