SUMMARY: Down-regulation of cytokine production in activated human blood monocytes (BMs) and alveolar macrophages (AMs) can be achieved in vitro by treatment with corticosteroids. The inhibition of cytokine secretion by corticosteroids may have important therapeutic consequences in e.g. asthma. Howe
Effect of adherence to plastic on peripheral blood monocyte and alveolar macrophage chemiluminescence
โ Scribed by de Sole, P. ;Fresu, R. ;Frigieri, L. ;Pagliari, G. ;de Simone, C. ;Guerriero, C.
- Publisher
- John Wiley and Sons
- Year
- 1993
- Weight
- 388 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0884-3996
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โฆ Synopsis
The chemiluminescence of peripheral blood monocytes and alveolar macrophages was determined in the presence of luminol and lucigenin, either before or after the cell adherence to the luminometer curvettes. In the case of monocytes, cell adherence induces an increase of luminol-dependent chemiluminescence and has almost no effect on the lucigenin-dependent chemiluminescence. However, it shows a strong inhibition of the lucigenin-dependent chemiluminescence and almost no effect on luminol-dependent chemiluminescence, in the case of alveolar macrophages. These results show that adhesion t o plastic alters the metabolic burst of both monocytes and alveolar macrophages. Although the mechanisms are poorly understood, they seem to be related t o the modifications that take place during the differentiation of peripheral monocytes t o alveolar macrophages.
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