Effect of adenovirus type 12 on tumor induction by SV40 and para (defective SV40)

✍ Scribed by Janet S. Butel; Joseph L. Melnick; Satvir S. Tevethia

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: French
• Weight: 509 KB
• Volume: 7
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910070113

✦ Synopsis

Abstract

PARA (defective SV40) was transcapsidated from adenovirus type 7 to the highly oncogenic Huie strain of adenovirus type 12. This transfer of PARA to adenovirus 12 was found to hasten the appearance of SV40‐type tumors in hamsters inoculated as newborns; the tumors induced by the PARA‐adenovirus 12 population had a latent period of 5–7 weeks. All the induced tumors contained SV40 and adenovirus tumor antigens. Parental SV40 and PARA‐adenovirus 7 did not induce any tumors in the same time period. Artificial mixtures of adenovirus 12 and SV40 or adenovirus 12 and PARA‐adenovirus 7 did induce tumors with short latent periods (5–7 weeks). However, in contrast to tumors induced by PARA‐adenovirus 12, all the early appearing tumors induced by the mixtures of virus were, with one exception, devoid of SV40 tumor antigen and contained only adenovirus tumor antigen. Tumors induced by PARA‐adenovirus 12 carried SV40 transplantation antigen.