Effect of adenovirus-mediated overexpression of decorin on metalloproteinases, tissue inhibitors of metalloproteinases and cytokines secretion by human gingival fibroblasts
β Scribed by Ayman Al Haj Zen; Antoine Lafont; Eric Durand; Camille Brasselet; Patricia Lemarchand; Gaston Godeau; Bruno Gogly
- Book ID
- 117640302
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 937 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0945-053X
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The influence of heparin and a heparin fragment devoid of anticoagulant activity on the production of matrix metalloproteinases and tissue inhibitors of metalloproteinases by human dermal fibroblasts was studied. Doses (0.1-400 g/ml) responses were performed and data obtained were similar whatever h
## Abstract Fibroblasts, a major constituent of gingival connective tissue, can produce immunoregulatory cytokines and proteolytic enzymes that may contribute to tissue destruction. In this study, we evaluated the production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), an