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Effect of Acute Renal Failure on Neurotoxicity of Cimetidine in Rats

โœ Scribed by Yu Nakada; Koujirou Yamamoto; Junichi Kawakami; Yasufumi Sawada; Tatsuji Iga


Book ID
110346245
Publisher
Springer US
Year
1995
Tongue
English
Weight
836 KB
Volume
12
Category
Article
ISSN
0724-8741

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Pharmacokinetic parameters of oltipraz were compared after intravenous and oral administration at a dose of 30 mg/kg to control rats and rats with U-ARF. After intravenous administration to rats with U-ARF, the AUC was significantly greater (1100 versus 1730 mg ร min/mL) than that in control rats, a