Effect of acute ethanol administration on brain levels of tetrahydropapaveroline in L-dopa-treated rats
β Scribed by Dr. J. L. Cashaw; C. A. Geraghty; B. R. McLaughlin; V. E. Davis
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 584 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0360-4012
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β¦ Synopsis
The effect of ethanol on the concentration
π SIMILAR VOLUMES
Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in
Normal rats and those pretreated with reserpine or cr were given L-DOPA alone or with extracerebral decarboxylase inhibitor (Ro 4-4602). l~otility was measured at two different time intervals and the brain levels of noradrenaline (NA) and dopamine (DA) were subsequently determined. No simple correl