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Effect of actinomycin D onTrypanosoma cruzi

✍ Scribed by M. Queiroz da Cruz; H. M. Bräscher; J. R. Vargens; A. Oliveira-Lima

Publisher
Springer
Year
1991
Tongue
English
Weight
384 KB
Volume
47
Category
Article
ISSN
1420-682X

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Selective and reversible effects of vinc
Selective and reversible effects of vinca alkaloids onTrypanosoma cruzi epimastigote forms: Blockage of cytokinesis without inhibition of the organelle duplication
✍ Grellier, Philippe ;Sinou, V�ronique ;Garreau-de Loubresse, Nicole ;Byl�n, Eva ; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 866 KB

Vinca alkaloids, vincristine and vinblastine, produce differential effects on the cell division of Trypanosoma cruzi epimastigote forms depending on drug concentrations. These effects are related to different microtubule-based mechanisms. For 15 microM vinblastine and 50 microM vincristine, the drug