Effect of ACTH and corticosterone on melanogenesis and cyclic nucleotide levels in the B-16 melanoma

✍ Scribed by Joel Abramowitz; Walter Chavin

• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 359 KB
• Volume: 264
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412656

✦ Synopsis

The acute in vitro action of ACTH and corticosterone individually and in combination were determined in the B-16 melanoma grown in vivo. ACTH elevated levels 10-fold while tyrosinase activity generally was depressed. Corticosterone depressed cAMP levels and tyrosinase activity. ACTH in the presence of corticosterone produced a coincident peak in tyrosinase activity and cAMP levels followed by a depression of enzymatic activity. The results demonstrate that cAMP is not the sole modulator of tyrosinase activity and that ACTH, corticosterone and cAMP interact in the regulation of B-16 melanoma tyrosinase activity.