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Effect of acetylation and permethylation on the conformation and candidacidal activity of salivary histatin-5

✍ Scribed by Kalaiyarasi Ramalingam; Narayanan Ramasubbu; Michael J. Levine

Book ID
104632804
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
608 KB
Volume
3
Category
Article
ISSN
1573-3149

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✦ Synopsis

Salivary histatins provide the non-immune defense against oral pathogens such as Candida albicans. The structural requirements of histatin-5 for anticandida activity were examined with respect to its ability to adopt helical structures, its electrostatic interactions and the hydrogen-bonding potency of its basic residues. For this purpose, the lysine and/or histidine residues of histatin-5 were chemically modified by acetylation and permethylation. Acetylated histatin-5 retained its ability to adopt helical structures in 2,2,2-trifluoroethanol, but completely lost its ability to kill yeast cells. In contrast, permethylated histatin-5 shows very little tendency to adopt a helical structure, but retained significant anticandida activity. The results suggest that the candidacidal activity can arise even when the histatin does not have the ability to adopt helical structures. The candidacidal activity of the derivatives is discussed in terms of electrostatic interactions and hydrogen-bonding potency.

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