✦ LIBER ✦

Effect of aberrant hepatic arterial anatomy on tumour response to hepatic artery infusion of floxuridine for colorectal liver metastases

✍ Scribed by D. Burke; S. Earlam; C. Fordy; Mr T. G. Allen-Mersh

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 346 KB
Volume: 82
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800820830

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✦ Synopsis

Regional hepatic artery infusion of colorectal liver metastases produces the highest reported treatment response. The effect of variation in hepatic artery anatomy on tumour response to regional floxuridine (FUdR) was studied. Aberrant hepatic arterial anatomy occurred in 13 of 74 patients (18 per cent) who underwent cannulation of the hepatic artery and infusion of FUdR for colorectal liver metastases. The non-dominant hepatic artery was ligated and the dominant artery cannulated in those with aberrant anatomy. Despite evidence of a collateral

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## Abstract 5‐Fluorouracil was administered by continuous hepatic intra‐arterial infusion to eight patients with the diagnosis of cancer of the gastrointestinal tract and hepatic metastases. Its elimination characteristics were investigated to see if they correlated with therapeutic effect or reduc