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Effect of a viral rep gene on transformation of cells by an adeno-associated virus vector

✍ Scribed by Ella Mendelson; Mervyn G. Smith; Irving L. Miller; Barrie J. Carter

Book ID: 113208973
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 831 KB
Volume: 166
Category: Article
ISSN: 0042-6822
DOI: 10.1016/0042-6822(88)90536-3

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## Abstract ## Background Adeno‐associated virus (AAV) vectors have been shown to correct a variety of mutations in human cells by homologous recombination (HR) at high rates, which can overcome insertional mutagenesis and transgene silencing, two of the major hurdles in conventional gene addition