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Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man

✍ Scribed by Timothy W. Evans; Gordon Dent; Duncan F. Rogers; Boonrut Aursudkij; K. Fan Chung; Peter J. Barnes


Book ID
117958800
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
613 KB
Volume
94
Category
Article
ISSN
0007-1188

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Effect of mequitamium iodide (LG 30435)
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Intravenous administration of mequitamium iodide (LG 30435) prevented the increase of tracheobronchial vascular permeability induced either by antigen challenge or by exogenous histamine in the guinea-pig, while it was ineffective against PAF, serotonin or capsaicin. These findings indicate that meq