Effect of a human serum thymic factor on hydrocortisone-treated thymocytes

✍ Scribed by Giulia C.B. Astaldi; A. Astaldi; Marjorie Groenewoud; P. Wijermans; P.Th.A. Schellekens; V.P. Eijsvoogel

• Book ID: 102825976
• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 559 KB
• Volume: 7
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830071203

✦ Synopsis

Abstract

A human serum thymic factor (SF) stimulated cyclic adenosine‐3′,5′‐mono‐phosphate (cAMP) synthesis in normal mouse thymocytes. Such stimulation was no longer observed when thymocytes were depleted of hydrocortisone (HC)‐sensitive cells. It was concluded that SF selectively stimulates cAMP in HC‐sensitive cells. Furthermore, incubation of thymocytes with SF enlarged the population of HC‐resistant thymocytes.

These results suggest that SF might act on HC‐sensitive thymocytes increasing their cellular cAMP level and inducing their transformation in HC‐resistant cells.