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Effect of a dioxin-like PCB (CB 126) on the biotransformation and genotoxicity of benzo[a]pyrene in the marine flatfish dab (Limanda limanda)

✍ Scribed by Arne van Schanke; Jan P Boon; Yvette Aardoom; Angela van Leest; Frederik Jan van Schooten; Lou Maas; Martin van den Berg; Jan M Everaarts

Book ID: 117346620
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 232 KB
Volume: 50
Category: Article
ISSN: 0166-445X
DOI: 10.1016/s0166-445x(00)00086-2

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## Abstract Polycyclic aromatic hydrocarbons (PAHs) are abundant pollutants, and many PAHs are carcinogenic, but only after metabolic activation. Benzo[__a__]pyrene (B __a__P) is among the most carcinogenic PAHs. The dose and time response of two enzymes involved in B __a__P metabolism and the amou