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Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

✍ Scribed by U. Noring; U. Juul Povlsen; D. E. Casey; J. Gerlach

Publisher
Springer
Year
1984
Tongue
English
Weight
241 KB
Volume
84
Category
Article
ISSN
0033-3158

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✦ Synopsis

RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5-4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatment with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.

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