Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion

Small molecule c-MET inhibitor PHA665752

Small molecule c-MET inhibitor PHA665752: Effect on cell growth and motility in papillary thyroid carcinoma

✍ Chandrani Chattopadhyay; Adel K. El-Naggar; Michelle D. Williams; Gary L. Clayma 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 879 KB

## Abstract ## Background c‐Met is upregulated in papillary thyroid carcinoma (PTC) and can be an attractive therapeutic target. We tested the effects of the small molecule c‐met inhibitor PHA665752 in blocking c‐met–dependent phenotypic effects in PTC cell lines. ## Methods PTC patient tissues