Possible carcinogenic effect of 6-mercap
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Jens Bo Thomsen; Henrik SchrΓΈder; Jon Kristinsson; Bibi Madsen; Carol Szumlanski
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Article
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1999
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John Wiley and Sons
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English
β 107 KB
BACKGROUND. 6-Mercaptopurine (6MP) has been regarded as nonleukemogenic, even though the cytotoxicity of 6MP depends on the incorporation of 6-thioguanine nucleotides (6TGN) into DNA. In hematopoietic cells this pathway competes with S-methylation catalyzed by thiopurine methyltransferase (TPMT). Ho