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Effect of 6-Mercaptopurine on Carbohydrate Metabolism of Human Cancer Cells

✍ Scribed by KATCHMAN, BERNARD J.; ZIPF, ROBERT E.; MURPHY, JAMES P. F.


Book ID
109622624
Publisher
Nature Publishing Group
Year
1962
Tongue
English
Weight
112 KB
Volume
195
Category
Article
ISSN
0028-0836

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BACKGROUND. 6-Mercaptopurine (6MP) has been regarded as nonleukemogenic, even though the cytotoxicity of 6MP depends on the incorporation of 6-thioguanine nucleotides (6TGN) into DNA. In hematopoietic cells this pathway competes with S-methylation catalyzed by thiopurine methyltransferase (TPMT). Ho