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Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRα1 and RET mRNAs in the adult rat

✍ Scribed by Amanda D Smith; Marci Antion; Michael J Zigmond; Mark C Austin


Book ID
117986097
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
315 KB
Volume
117
Category
Article
ISSN
0169-328X

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✍ C. Durand; A.M. Mathieu-Kia; M.-J. Besson; J. Penit-Soria 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

The intrastriatal injection of 6-hydroxydopamine (6-OHDA) in newborn rats produces a marked striatal dopamine (DA) depletion, accompanied by a serotonin (5-HT) hyperinnervation and an up-regulation of 5-HT receptors. The aim of the present study was to investigate whether the increase in 5-HT 2 rece