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Effect of 5′-methylthioadenosine on RNA and DNA synthesis in cultured Xenopus laevis cells

✍ Scribed by Ronald E. Law; Leo Miller

Book ID
115891687
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
372 KB
Volume
147
Category
Article
ISSN
0014-4827

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Effect of 5′-difluoromethylthioadenosine
Effect of 5′-difluoromethylthioadenosine, an inhibitor of methylthioadenosine phosphorylase, on proliferation of cultured cells
✍ Seiji Nishikawa; Akemichi Ueno; Hideo Inoue; Yoshiro Takeda 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 554 KB

5'-Met h ylt h ioadenosi n e (MTA) is formed from decarboxylated S-adenosyl methionine during biosynthesis of polyamines. This nucleoside is cleaved by methylthioadenosine phosphorylase (MTA Pase) to adenine and 5-methylthioribose-I-phosphate in mammalian cells. 5'-Difluoromethylthioadenosine (DFMTA