Effect of 4-hydroxynonenal on gene expression and differentiation of HL-60 human leukemic cells
β Scribed by G. Barrera; R. Muraca; C. Di Mauro; V.M. Fazio; M.U. Dianzani
- Book ID
- 119157431
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 172 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0277-5379
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When cultured in Mg restricted medium, human leukemic HL-60 cells develop morphological and functional granulocytic differentiation. In 0.03 mM Mg, cells display the distinctive features of differentiation, without appreciable inhibition of proliferation. In 0.01 mM Mg, cells show terminal different
## Abstract More than 80% of cells from a human promyelocytic leukemic cell line (HLβ60) possess the capacity for selfβrenewal as evidenced by their ability to form large primary colonies in semisolid medium and the presence within these colonies of cells capable of subsequent colony formation. Col