Effect of 4-aminopyridine on development of experimental botulinum poisoning
β Scribed by V. V. Morrison; G. N. Kryzhanovskii
- Publisher
- Springer US
- Year
- 1985
- Tongue
- English
- Weight
- 243 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0007-4888
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## Abstract The effect of intraperitoneally injected taurine against the convulsive activity induced by 4βaminopyridine (4βAP) was studied in 12β to 15βdayβold mice. At a dose of 2.6 mg/kg, taurine increased the latency of clonic seizures from 7 to 20 minutes, reduced the incidence of tonic seizure
## Abstract The effects of 4βaminopyridine (4βAP) on neuromuscular transmission were studied in vitro in the rat flexor digitorum longus muscles. 4βAP produced doseβdependent increases in endplate potential (EPP) amplitude, in rise time to peak, and in the average number of acetylcholine quanta rel
The effects of 4-aminopyridine (4-AP) and of taurine on the guinea pig ileum were examined. Four-AP increases the basal activity from 1.3 to 6.45 cm2/min. This effect is atropine-sensitive and calcium-dependent. Taurine counteracts the effects of 4-AP on muscle contracture in a concentration-depende