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Effect of 18 HR fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats

โœ Scribed by Rudolph J. Jaeger; Rory B. Conolly; Sheldon D. Murphy


Book ID
113146995
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
858 KB
Volume
20
Category
Article
ISSN
0014-4800

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The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33%

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