Effect of 17β-estradiol on the brain damage and metabolic changes in rats
✍ Scribed by Jincao, Chen ;Ting, Lei ;Ritz, M. -F. ;Mendelowitsch, A.
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 389 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0257-716X
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## Abstract Developing oligodendrocytes (pre‐OLs) are highly vulnerable to hypoxic‐ischemic injury and associated excitotoxicity and oxidative stress. 17β‐Estradiol plays an important role in the development and function of the CNS and is neuroprotective. The sudden drop in circulating estrogen aft
The acute effects of 17 beta-estradiol on brain excitability were studied in vitro and in vivo utilizing rat hippocampal slices and a cat cerveau isolé preparation. The hippocampal slices were perfused with 17 beta-estradiol (10(-7)-10(-10) M) for 30 min. No effects were observed on synaptic activat