Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells
โ Scribed by Yingfang SONG; Haowen QI; Changgui WU
- Book ID
- 108964668
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 212 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1323-7799
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In addition to a role in calcium and phosphate homeostasis other vitamin D receptor (VDR) mediated effects have been discovered during the past few years for the biologically active metabolite of vitamin D, 1,25(OH)2D 3. An antiproliferative, differentiation-inducing effect on nonmalignant and neopl
1,25-(OH) 2 D 3 (1,25) and 24,25-(OH) 2 D 3 (24,25) mediate their effects on chondrocytes through the classic vitamin D receptor (VDR) as well as through rapid membrane-mediated mechanisms, which result in both nongenomic and genomic effects. In intact cells, it is difficult to distinguish between g