Effect of 1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells
✍ Scribed by Lixin Cui; Abdesslem Faraj; Jean-Pierre Sommadossi
- Book ID
- 114145248
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 741 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0166-3542
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (
The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C