Efaroxan, an alpha-2 antagonist, in the treatment of progressive supranuclear palsy
✍ Scribed by Prof. Olivier Rascol; Kasia Sieradzan; Hélène Peyro-Saint-Paul; Claire Thalamas; Christine Brefel-Courbon; Jean Michel Senard; Philippe Ladure; Jean Louis Montastruc; Andrew Lees
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 413 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
We have tested, in a prospective randomized, double‐blind, placebo‐controlled, crossover, 12‐week study, the effects of 2 mg efaroxan, a potent alpha‐2 antagonist, given three times per day to 14 patients with progressive supranuclear palsy. Efaroxan did not induce any significant change on any motor assessment criteria. The present data do not confirm the assumption that the blockade of alpha‐2 receptors might be a useful pharmacologic strategy to improve patients with progressive supranuclear palsy.