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Efalizumab Down-regulates CD25 Expression on FOXP3+ Regulatory T Cells and Exacerbates the Autoimmunity in Primary Sjogren's Syndrome

✍ Scribed by Dat Tran; Lolita Bebris; Ethan Shevach; Gabor Illei


Book ID
113541584
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
46 KB
Volume
135
Category
Article
ISSN
1090-2341

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## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the