EEG profiles of fenfluramine, amobarbital and dextroamphetamine in normal volunteers

✍ Scribed by Max Fink; Donald M. Shapiro; Turan M. Itil

• Book ID: 104760873
• Publisher: Springer
• Year: 1971
• Tongue: English
• Weight: 780 KB
• Volume: 22
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00406875

✦ Synopsis

A quantitative EEG study in volunteer adults was undertaken to distinguish single oral administrations of 50 and 100 mg amobarbital, 10 mg dextroamphetamine, 40 mg fenfluramine and placebo. X~our hour EEG recordings were monitored by frequent auditory reaction time tasks. The EEG changes were measured by digital computer period analysis.

In the analysis, each drug was distinguished from placebo, and from each other, with the best discriminations for 50 mg amobarbital and dextroamphetamine, and the poorest discrimination of fenfluramine from 50 mg amobarbital.

These observations are consistent with the clinical pharmacology of the compounds and suggest further applications of quantitative EEG for the classification of psychoactive drugs.