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Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

✍ Scribed by Yuji Yamazaki; Junko Kon; Koichi Sato; Hideaki Tomura; Motoko Sato; Takashi Yoneya; Hiroshi Okazaki; Fumikazu Okajima; Hideo Ohta


Book ID
115585255
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
100 KB
Volume
268
Category
Article
ISSN
0006-291X

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be