Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells
β Scribed by R. Mark Richardson; Binh Nguyen; Shawn E. Holt; William C. Broaddus; Helen L. Fillmore
- Book ID
- 116769560
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 986 KB
- Volume
- 421
- Category
- Article
- ISSN
- 0304-3940
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## Abstract Upon treatment with retinoic acid, NTeraβ2 (NT2) human teratocarcinoma and SKβNβSH neuroblastoma cells can be induced to terminally differentiate into postmitotic neuronal cells. The neuronal cell yield obtained from the NTβ2 cells is partially dependent on the time of differentiation (
## Abstract Connexinβmediated gap junctions and open hemichannels in nonjunctional membranes represent two biologically relevant mechanisms by which neural progenitors can coordinate their response to changes in the extracellular environment. NT2/D1 cells are a teratocarcinoma progenitor line that