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Ectopic production of beta-HCG by a maxillary squamous cell carcinoma

✍ Scribed by Peter D. Scholl; Stephen Jurco; John R. Austin

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
878 KB
Volume
19
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. Paraneoplastic syndromes of the head and neck are rare. Hypercalcemia and leukocytosis have been described. The literature was reviewed, and a case of a squamous cell carcinoma of the maxilla producing beta human chorionic gonadotropin (beta-HCG) is presented.

Methods. A 47-year-old white man with a T4N1M0 squamous cell carcinoma of the left maxilla was treated with a maxillectomy and neck dissection for an N1 positive neck. After completing his planned radiotherapy, he developed distant metastases, which included an axillary node that stained positive for human beta-HCG.

Results. Retrospective review of the primary specimen showed beta-HCG positivity in an anaplastic component of the tumor along with vascular invasion.

Conclusions. The first case in the literature of a paraneoplastic syndrome with beta-HCG production in association with squamous cell carcinoma of the maxilla is presented. This case history fits the aggressive nature of beta HCG producing tumors elsewhere in the body.

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