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ECTO-enzyme activity of human erythrocyte adenosine deaminase

✍ Scribed by Ken Bielat; George L. Tritsch


Publisher
Springer
Year
1989
Tongue
English
Weight
643 KB
Volume
86
Category
Article
ISSN
0300-8177

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Adenosine deaminase (ADA, E.C. 3.5.4.4) is an enzyme of the purine metabolism that converts adenosine (Ado) and 2β€²deoxyadenosine (dAdo) into inosine and 2β€²deoxyinosine, respectively. The enzyme has been the object of considerable interest because the congenital defect causes severe combined immunode

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We report a case of primary acquired slderoblastic anemia (PASA) associated with elevated erythrocyte adenosine deaminase (ADA) activity. The patient was an 85-yearold Japanese male. Analysis of the peripheral blood revealed pancytopenia, and the bone marrow findings showed marked ringed sideroblast