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Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

✍ Scribed by J.P. Capela; K. Ruscher; M. Lautenschlager; D. Freyer; U. Dirnagl; A.R. Gaio; M.L. Bastos; A. Meisel; F. Carvalho


Book ID
116787612
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
829 KB
Volume
139
Category
Article
ISSN
0306-4522

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✍ Mark A. DeCoster; Gerard Lambeau; Michel Lazdunski; Nicolas G. Bazan πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 762 KB

## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamate‐induced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe