Eco-friendly, solvent-free novel one-pot, three-component synthesis of quinazolinones at ambient temperature catalyzed by silica gel-supported phosphomolybdic acid

✍ Scribed by Gowravaram Sabitha; N. Mallikarjuna Reddy; M. Nagendra Prasad; G. S. K. Raja; J. S. Yadav

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 116 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.361

✦ Synopsis

Abstract

magnified image Silica gel supported Phosphomolybdic acid (PMA.SiO~2~) catalyzes efficiently the one‐pot three‐component coupling reaction of anthranilic acid, orthoesters, and amines at room temperature to afford 4(3__H__)‐Quinazolinones in high to excellent yields under solvent‐free conditions. The supported catalyst can be recovered and reused. J. Heterocyclic Chem., (2010).