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EBV-Infected B Cells in Infectious Mononucleosis: Viral Strategies for Spreading in the B Cell Compartment and Establishing Latency

✍ Scribed by Julia Kurth; Tilmann Spieker; Jochen Wustrow; John G Strickler; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers

Book ID
117722400
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
409 KB
Volume
13
Category
Article
ISSN
1074-7613

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We examined the patterns of viral gene expression in acute infectious mononucleosis (IM) patients and the clonality of the directly growing EBV-carrying cell lines. Both low- and high-density EBV-carrying B cells obtained from the patients' tonsils expressed EBNA1, EBNA2 and LMP1. Like LCLs and immu