๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

EASL news: novel candidates for the fight against hepatitis C

Book ID
120844591
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2008
Weight
183 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of the guanine nucleoside. Modification of the ester an