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Earrings and padlocks for the double helix: topological labeling of duplex DNA

✍ Scribed by Vadim V. Demidov


Book ID
114152630
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
90 KB
Volume
21
Category
Article
ISSN
0167-7799

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A family of bis-[4Ј-Azido-2,2Ј:6Ј,2Π‰-terpyridine platinum(II)] complexes with linear linkers of varying length have been synthesized. They have been designed to bis-intercalate into two DNA duplexes in close proximity, the azido groups allowing the sites of intercalation to be photoaffinity labeled.