Alpha-synuclein dysfunction in Lewy body
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George K. Tofaris; Maria Grazia Spillantini
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Article
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2005
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John Wiley and Sons
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English
⚖ 116 KB
alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments o