Clofarabine (40 mg/m^2^/day × 5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m^2^/day × 5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (__N__ = 4) and relapsed (__N__ = 17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myel
Early UK experience in the use of clofarabine in the treatment of relapsed and refractory paediatric acute lymphoblastic leukaemia
✍ Scribed by David O’Connor; Keith Sibson; Mark Caswell; Philip Connor; Michelle Cummins; Chris Mitchell; Jayashree Motwani; Mary Taj; Ajay Vora; Robert Wynn; Pamela R. Kearns
- Book ID
- 108677330
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 66 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0007-1048
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## Abstract The standard dose of clofarabine is 52 mg/m^2^ for pediatrics and 40 mg/m^2^ in adults. Clofarabine dosed at 52 mg/m^2^ was used in adult patients with refractory ALL to maximize response before allo‐HSCT. All patients had a significant response to therapy. Published pharmacokinetic ana
## Abstract Clofarabine is a second generation nucleoside analogue. It inhibits DNA repair and activates the mitochondrial apoptotic pathway leading to cell death. __In vitro__ clofarabine has demonstrated synergy with daunorubicin and Ara‐C and in phase II clinical trials has shown promising activ
Serial liver function tests and percutaneous liver biopsies were performed on 21 children receiving treatment for acute lymphoblastic leukaemia (ALL). The patients received continuing chemotherapy either with daily 6-mercaptopurine and weekly methotrexate or with five-day pulses of these drugs every